Library
The latest research to explore
Do I carry a protective FNIP1 variant for metabolic health?
Direct Genome Prompt
Analyze rare protein-truncating variants in FNIP1 and explain their human associations with lipids, fat distribution, lean mass, blood sugar, liver fat and cardiometabolic disease. Discuss FNIP2 and FLCN only as experimental pathway genes, not equivalent protective human variants.
Am I more likely to have side effects from SSRI antidepressants?
Direct Genome Prompt
Analyze CYP2C19*2 rs4244285, *3 rs4986893 and *17 rs12248560. Determine my metabolizer status and explain the study’s associations with escitalopram, citalopram and sertraline side effects, including sleep problems, sexual dysfunction and tremor.
Am I predisposed to borderline personality disorder?
Direct Genome Prompt
Analyze the 11 lead variants rs2143288, rs9970854, rs12466671, rs6549383, rs2135029, rs4727799, rs10953781, rs73581580, rs7304862, rs7210027 and rs5944622. Explain the implicated genes; calculate predisposition only from a complete weighted study score.
Do my variants lean toward more REM, non-REM or total sleep?
Direct Genome Prompt
Interpret complete study-matched scores for REM, non-REM and total sleep if available. Explain the main contributing variants and keep the three objectively measured sleep phenotypes separate.
Do my variants overlap endometriosis and adenomyosis risk?
Direct Genome Prompt
Interpret complete study-matched scores for endometriosis and adenomyosis if available. Highlight shared and distinct variants near WNT4, GREB1, ESR1, VEZT, CDKN2B-AS1 and KDR.
Am I at risk of severe nausea and vomiting during pregnancy?
Direct Genome Prompt
Analyze rs56337209, rs9312688, rs10073299, rs10948901, rs76856932, rs7101406, rs12790159, rs17077610, rs1058587 and rs5994661 individually. Explain each study association and the implicated genes. Interpret them as individual lead-variant associations rather than a complete risk score.
Do I carry the HIF1A variant linked to slower MS progression?
Direct Genome Prompt
Analyze HIF1A rs11621525-A. Count the protective allele and explain its reported associations with long-term disability, paramagnetic rim lesions, neurofilament levels and smouldering inflammation in multiple sclerosis.
Do I carry a CHRNB3 variant linked to smoking fewer cigarettes?
Direct Genome Prompt
Analyze CHRNB3 p.Glu284Gly and rare stop-gain, frameshift or essential splice variants. Explain their reported effects on receptor function and cigarettes smoked per day.
Do I carry the APOE-region deletion linked to lower Alzheimer’s risk?
Direct Genome Prompt
Analyze the APOE-region deletion rs148353395 together with rs429358 and rs7412. Determine my supported APOE ε2/ε3/ε4 genotype and explain how the deletion was associated with Alzheimer’s risk in African American participants.
Do I carry variants linked to menopausal hot flashes?
Direct Genome Prompt
Analyze rs13107507 and study-matched lead variants in the TACR3 region. Explain their reported associations with menopausal hot flashes and highlight TACR3, GRID1, NUDT4 and PHF21B.
Do I carry the MSI2 variant linked to less clonal haematopoiesis?
Direct Genome Prompt
Analyze rs17834140 near MSI2. Count the T allele and explain its reported associations with MSI2 expression, clonal haematopoiesis and blood-cell clone growth.
Do I carry the CSF2RB variant linked to experimental Alzheimer’s resilience?
Direct Genome Prompt
Analyze the exact CSF2RB p.Ala455Asp variant. Explain its experimental effects on microglial inflammation, phagocytosis and neuronal preservation, distinguishing model evidence from demonstrated human Alzheimer’s protection.
How strong is my inherited predisposition to hypothyroidism?
Direct Genome Prompt
Interpret a complete, ancestry-appropriate hypothyroidism polygenic score if available. Highlight contributing variants near TSHR, FOXE1, TPO, TG, HLA and CTLA4 and explain the roles of thyroid biology and autoimmunity.
Do I carry PTPRT or POMC variants linked to body weight?
Direct Genome Prompt
Analyze PTPRT p.Arg1384His and POMC p.Glu206Ter. Explain the direction and size of their reported associations with body mass index in the Estonian Biobank.
Do I carry two copies of the CD36 cardiomyopathy variant?
Direct Genome Prompt
Analyze CD36 rs3211938. Determine my G-allele count and explain the association between the G/G genotype, reduced cardiac function and dilated cardiomyopathy in the studied African-ancestry cohorts.
Does NR3C1 rs6190 alter my muscle stress response?
Direct Genome Prompt
Analyze NR3C1 rs6190. Explain the allele’s experimental effects on glucocorticoid signalling, FOXC1 and ARID5A regulation, insulin sensitivity and exercise tolerance.
Do my variants differ for leisure, work and household activity?
Direct Genome Prompt
Analyze rs761898, rs7613360, SLC39A8 rs13107325 and CADM2 rs62253088, plus complete study-matched scores for leisure, occupational and household activity if available. Explain the three activity contexts separately.
Do I carry stuttering-associated variants?
Direct Genome Prompt
Analyze rs35609938 and rs1040225 at the VRK2/FANCL locus and any complete study-matched stuttering score. Explain the sex- and ancestry-specific study context without treating two lead variants as a full prediction.
Does my wider genetic profile affect antidepressant side effects?
Direct Genome Prompt
Analyze any complete, study-matched polygenic scores for the 25 antidepressant side-effect phenotypes. Examine CYP2C19 rs4244285, rs4986893 and rs12248560 as one pharmacokinetic component, keeping broad side-effect susceptibility separate from SSRI-specific metabolizer effects.
Do I carry the FOXP4 variant linked to long COVID?
Direct Genome Prompt
Analyze rs12660421 near FOXP4. Count the study’s effect allele and explain its association with long-COVID risk and FOXP4 expression in lung tissue.
Do I carry variants linked to reduced sperm production?
Direct Genome Prompt
Analyze rs34915133-G in the MHC class II region and rs10842262 near SOX5. Explain their reported associations with idiopathic spermatogenic failure and Sertoli cell-only syndrome.
Do I carry variants linked to infertility?
Direct Genome Prompt
Analyze rs9643050, GPC2 GRCh38 chr7:100171569 G>A and STAG3 chr7:100204708 C>T, plus rare high-impact variants in AKR1D1, AKR1C3, HSD11B1, HSD17B2, TRIM4 and CYP3A43. Explain the associated infertility phenotypes.
How do rare cardiomyopathy variants and common heart-failure risk combine?
Direct Genome Prompt
Analyze pathogenic or loss-of-function variants in TTN, MYBPC3, FLNC and BAG3. If a complete study-matched heart-failure polygenic score is available, interpret it separately and explain how common risk can modify rare-variant penetrance.
Which reproductive-health associations appear in my genome?
Direct Genome Prompt
Analyze exact study-matched lead variants for reproductive diagnoses represented in my genome, including rs200315340 near MYH11 for uterine fibroids. Highlight signals involving WNT4, PAX8, FSHB and CHEK2, keeping each diagnosis separate.
Do I carry FRS3 variants linked to higher or lower body weight?
Direct Genome Prompt
Analyze FRS3 p.Glu115Lys, rs146730626 and rs35744673, plus any supported MC4R-region deletion. Explain the ancestry-specific directions and effect sizes reported for body mass index.
Do I carry the PLCG2 variant linked to Alzheimer’s resilience?
Direct Genome Prompt
Analyze PLCG2 rs72824905-G (p.Pro522Arg). Count the G allele and explain its reported association with Alzheimer’s risk and its experimental effects on microglial responses to amyloid.
Do I carry TCL1B variants linked to clonal haematopoiesis?
Direct Genome Prompt
Analyze TCL1B rs187319135-T and rs774615666-T, alongside rs10131341 and rs2887399 at TCL1A/TCL1B. Explain their population frequencies and driver-gene-specific associations with clonal haematopoiesis.
How strong is my inherited predisposition to chronic back pain?
Direct Genome Prompt
Interpret a complete study-matched chronic-back-pain polygenic score if available. Highlight contributing variants near SOX5, CCDC26/GSDMC, DCC and SPOCK2 and explain the implicated nervous-system and pituitary pathways.
Do my genes shift my baseline PSA level?
Direct Genome Prompt
Interpret a complete study-matched PSA polygenic score and explain variants that influence baseline prostate-specific antigen levels. Distinguish inherited PSA variation from variants associated with prostate cancer susceptibility.
Could DPYD or UGT1A1 variants increase my chemotherapy toxicity risk?
Direct Genome Prompt
Analyze DPYD rs3918290, rs55886062, rs67376798, rs56038477 and rs115232898, plus the UGT1A1*28 repeat rs8175347. Determine the supported DPYD and UGT1A1 metabolizer phenotypes and explain their relevance to fluoropyrimidine or irinotecan toxicity.
Do I carry the shared rhythm–dyslexia variant?
Direct Genome Prompt
Analyze PPP2R3A rs28576629 and any complete study-matched rhythm or dyslexia scores. Explain the variant’s association with the shared genetic factor while keeping rhythm ability and dyslexia as distinct traits.
Do I carry rare GDF15 loss-of-function variants?
Direct Genome Prompt
Analyze rare stop-gain, frameshift and essential splice variants in GDF15. Determine whether one or both gene copies may be disrupted and explain the human-knockout findings for GDF15 levels, appetite, metabolism and pregnancy biology.
Do I carry the SMIM1 deletion linked to metabolism and the Vel blood group?
Direct Genome Prompt
Analyze the SMIM1 c.64_80del 17-base-pair deletion. Determine whether I may be Vel-negative and explain the reported associations with resting energy expenditure, body weight and blood lipids.
Do rare DNA-repair variants affect my reproductive ageing and cancer risk?
Direct Genome Prompt
Analyze rare loss-of-function or clinically pathogenic variants in ZNF518A, BRCA2, CHEK2 and HELB. Explain their reported relationships with menopause timing, ovarian ageing and established cancer susceptibility.
Do I carry variants linked to lower influenza risk?
Direct Genome Prompt
Analyze ST6GAL1 rs16861415-C and B3GALT5 rs2837112-A. Count each protective allele and explain the reported associations with influenza infection and, where studied, influenza-related hospitalization.
Could ABCG2 or MOCOS variants reduce my response to allopurinol?
Direct Genome Prompt
Analyze ABCG2 rs2231142 and rare high-impact variants in MOCOS. Determine the supported ABCG2 transporter phenotype and explain the reported associations with urate lowering during allopurinol treatment.
Do I carry two copies of the CCDC201 early-menopause variant?
Direct Genome Prompt
Analyze CCDC201 rs117316434 (GRCh38 chr7:45863165 G>A; p.Arg162Ter). Determine my A-allele count and explain the study’s association between the A/A genotype, primary ovarian insufficiency and menopause timing.
Do my variants lean toward earlier or later puberty?
Direct Genome Prompt
Analyze FSHB rs11031006, MC3R rs3746619 and GPR83 rs592068, plus rare high-impact variants in MKRN3, DLK1, KISS1, KISS1R, TAC3 and TACR3. Explain their reported directions for puberty timing.
Do I carry variants linked to postpartum haemorrhage?
Direct Genome Prompt
Analyze rs13141656 near HAND2 and study-associated variants at PHACTR2, ZEB1, TBX3 and RAP2C/FRMD7. Explain each allele’s reported relationship with postpartum-haemorrhage risk and uterine biology.
How strong is my inherited predisposition to restless legs syndrome?
Direct Genome Prompt
Interpret a complete study-matched restless-legs-syndrome polygenic score if available. Highlight contributing variants near MEIS1, BTBD9, PTPRD, MAP2K5/SKOR1 and TOX3 and explain the neuronal and iron-related pathways.
Do I carry the ADARB2 variant linked to being headache-free?
Direct Genome Prompt
Analyze ADARB2 rs7904615-G. Count the G allele and explain the replicated association with complete freedom from headache.
Does my genome contain a medically actionable variant?
Direct Genome Prompt
Analyze clinically classified variants in established actionable genes, including HFE rs1800562 and TTR rs76992529. Explain any pathogenic or likely pathogenic findings and their associated conditions.
Do I carry the FN1 variant linked to Alzheimer’s resilience?
Direct Genome Prompt
Analyze FN1 rs140926439 together with APOE rs429358 and rs7412. Explain whether my genotype matches the Alzheimer’s-resilience association reported specifically among APOE ε4 carriers.
Do I carry a BSN variant linked to adult-onset obesity?
Direct Genome Prompt
Analyze rare protein-truncating variants in BSN, including stop-gain, frameshift and essential splice variants. Explain their reported associations with adult-onset severe obesity, type 2 diabetes and fatty liver disease.
Do I carry the RGL3 deletion linked to lower blood pressure?
Direct Genome Prompt
Analyze structural-variant calls for the reported partial exon 6 deletion in RGL3. Explain its association with blood pressure and hypertension only if the matching deletion is represented.
Do I carry two pathogenic PRKN variants linked to early-onset Parkinson’s?
Direct Genome Prompt
Analyze pathogenic or likely pathogenic PRKN variants, including supported exon-level deletions and duplications. Determine whether two variants affect separate gene copies and explain how variant type and position relate to early-onset Parkinson’s disease.
Does SLCO1B1 affect which statins I may tolerate?
Direct Genome Prompt
Analyze SLCO1B1 rs4149056 and the supported SLCO1B1 diplotype or transporter phenotype. Explain how reduced function changes exposure and muscle-symptom risk for relevant statins, especially simvastatin.
Is my pregnancy-nausea sensitivity linked to GDF15?
Direct Genome Prompt
Analyze GDF15 p.Cys211Gly and rs1054221. Explain how my alleles relate to circulating GDF15 and the study’s model of maternal sensitivity to placental GDF15 during pregnancy.
Do I carry rare migraine-associated variants?
Direct Genome Prompt
Analyze rare high-impact or migraine-associated variants in PRRT2, SCN11A and KCNK5, and relevant signals near PALMD, ABO and LRRK2. Explain whether findings were associated with migraine with aura, without aura or both.
Do my variants lean toward shorter or longer habitual sleep?
Direct Genome Prompt
Interpret complete study-matched scores for short and long habitual sleep if available. Keep the two phenotypes separate and explain the main contributing loci and their overlap with depression-related genetics.
Do I carry rare SLC13A1 variants linked to chronic pain?
Direct Genome Prompt
Analyze rare stop-gain, frameshift, essential splice or clearly damaging variants in SLC13A1. Explain the study’s gene-level association with chronic pain and the proposed role of sulphate transport.
Do I carry the DYSF–ZNF638 variant linked to faster MS disability?
Direct Genome Prompt
Analyze rs10191329 at DYSF–ZNF638 and rs149097173 at DNM3–PIGC. Explain their reported associations with MS disability severity, distinguishing the genome-wide-significant result from the suggestive signal.
Do I carry the RELN variant linked to delayed Alzheimer’s symptoms?
Direct Genome Prompt
Analyze the exact RELN p.His3447Arg variant. Explain whether my genotype matches the exceptional Alzheimer’s-resilience case and why evidence from one PSEN1 E280A carrier does not establish general protection.